Table 2. Drug Interactions: Combined Oral Contraceptives and Antiretroviral (ARV) Medications
While there is some theoretical concern that ARVs might reduce the effectiveness of combined oral contraceptives (COCs), women taking ARVs can still generally use COCs. Providers can use the table below to guide counseling and prescribing. In general, if a woman using ARVs wants to use COCs, she can be given a formulation with at least 30µg of estrogen, counseled about the importance of taking COCs every day (without missing pills), and encouraged to use condoms consistently. Correct and consistent condom use would help to make up for any decrease in effectiveness of the oral contraceptives as well as help to protect an uninfected sexual partner (195).
|
ARV
|
Effect on Contraceptive Hormone Level*
|
Effect on ARV Level
|
|
Protease inhibitors (PIs)
|
|
Amprenavir
|
Increase
|
Decrease
|
|
Atazanavir
|
Increase
|
No data
|
|
Darunavir
|
Decrease
|
No change
|
|
Fosamprenavir
|
Decrease
|
Decrease
|
|
Indinavir
|
Increase
|
No data
|
|
Lopinavir + Ritonavir
|
Decrease
|
No data
|
|
Nelfinavir
|
Decrease
|
No data
|
|
Ritonavir
|
Decrease
|
No data
|
|
Saquinavir
|
No change
|
No change
|
|
Tenofovir
|
No change
|
No change
|
|
Tipranavir
|
Decrease
|
Decrease
|
|
Non-nucleoside reverse transcriptase inhibitors (NNRTIs)
|
|
Delavirdine
|
May increase
|
No data
|
|
Efavirenz
|
Increase
|
No change
|
|
Nevirapine
|
Decrease
|
No data
|
*Estrogen levels only
Sources: Adapted from World Health Organization 2004 (248). Additional information from HIV InSite 2007 (90) and U.S. Department of Health and Human Services 2006 (166)
|